Study 2
OBJECTIVE:
Comparison of epidermal cell proliferation produced by SESHA SKIN THERAPY A.C.E. Cream containing PET™ nutrient delivery system with Retin-A Cream (0.025%) and Oil of Olay Original Beauty Fluid.
PROTOCOL AND STUDY PARAMETERS:
7-day in-vivo study
RESULTS:
The A.C.E Cream significantly thickened the epidermis. The skin is plump and has characteristics of young, healthy skin.
Retin-A 0.025% produced a slight increase of skin cells, but the epidermis is damaged.
Oil of Olay did not show signs of cell proliferation.
CONCLUSION:
Biopsies stained with hematoxylin and eosin at 400x magnification show that A.C.E. Cream is an effective stimulator of epidermal cells.
Study conducted by Peter T. Pugliese, M.D.
Table #1 – Epidermal Thickness in microns (micrometers):
| SUBJECT | A.C.E. CREAM | RETIN-A 0.025% | OIL OF OLAY |
|---|---|---|---|
| A B C D E |
50.3 47.3 59.5 58.3 51.5 |
33 34 39 39 36 |
19.8 21 18 21 21 |
| MEAN | 53.4 | 36.2 | 20.2 |
Hematoxylin and Eosin Stain of sample skin biopsies at 400x :
