Evaluation of the in vitro percutaneous permeation enhancement of 1% clotrimazole preparation containing 4% PET™. Permeation results are compared to an experimental control (1% clotrimazole gel without PET™) and, a commercially available preparation of 1% clotrimazole (Lotrimin® AF topical solution).


Percutaneous permeation of preparations were tested and measured in the in vitro Franz skin diffusion cells over 72 hour time period.


The 4% PET™ containing clotrimazole preparations showed about a 3-fold greater permeation of clotrimazole into the in vitro skin than the preparation without PET™.

Chart #1- In Vitro / In Vivo Correlation